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Description
Human TrkB , His tagProduct Specification Species Human Synonyms GP145 TrkB (Trk B), Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin related kinase B, NTRK2 Accession Q16620 Amino Acid Sequence Protein sequence(Q16620, Trp230 His430, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | GP145-TrkB (Trk-B), Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B, NTRK2 |
| Accession | Q16620 |
| Amino Acid Sequence | Protein sequence(Q16620, Trp230-His430, with C-10*His) WDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHGGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:24kDa Actual: 35-45kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
Tropomyosin receptor kinase B is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB are: BDNF (Brain Derived Neurotrophic Factor), neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3). Although originally identified as an oncogenic fusion in 1982, only recently has there been a renewed interest in the Trk family as it relates to its role in human cancers because of the identification of NTRK1 (TrkA), NTRK2 (TrkB) and NTRK3 (TrkC) gene fusions and other oncogenic alterations in a number of tumor types. A number of Trk inhibitors are in clinical trials and have shown early promise in shrinking human tumors. TrkB and its ligand BDNF have been associated to both normal brain function and in the pathology and progression of Alzheimer’s disease (AD) and other neurodegenerative disorders.
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Exchange/Return Notes
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4.2 ★★★★★
Based on 1208 reviews
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Product Reviews
★★★★★ 5
Love denim and tired of cropped jackets?
Fit Type: Oversized, Size: Large, Color: Medium Blue Vintage
I like this a lot, it was what I was looking for as far as I'm so over everything you buy these days is cropped. Cropped styles are great, but are kind of getting old for some things in my opinion. The jacket is big as far as how it fits. I am 5'8" about 180 and I wish I would have got a medium, I got a large.
The large is big and roomy enough that I could even wear ear a thick hoodie under it if I wanted to. However, the length is good as what I was looking for. The upper arms are large. However, this is a great quality denim jacket. Nice and thick, sturdy material (which I wanted).
It's also at a great, competitive low price even if it's not on sale. Don't believe me, go ahead and search jean jackets. You'll see a ton, but I looked too and the quality did not look as good as this and plus the other jackets were a lot more for a lot less. If you're looking for a longer jean jacket, I highly recommend this.
I'd say just think seriously about sizing down 1... even maybe 2 sizes. I would have gotten an XL before I read the other reviews. They recommended to size down, and after getting my jacket I could have sized down to a medium. I'm still happy with it and this is a jacket that is stitched well and will last a very long time.
As always though, that's just my 2 cents. :)
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Reviewed in the United States on January 19, 2026
★★★★★ 4
Nice quality, shape not for me
Fit Type: Oversized, Size: Medium, Color: Medium Blue Vintage
This was just too boxy for my body. Material was nice, quality jean material. Color was true to image. It was a little stiff but as you would expect with nice, new and unwashed denim.
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Reviewed in the United States on May 31, 2026
★★★★★ 5
Solid basic good denim jacket
Fit Type: Regular, Size: X-Large, Color: Authentic Medium Wash
In direct comparison to Levi’s women’s trucker denim jacket, this one is: slightly heavier denim, less stretchy, less fitted. I kept this one and returned the Levi’s because I wanted the roomier fit. I wish it was a little longer in the body: I’m tall, and it isn’t too short but I’d like a little more length. It feels slightly longer than the Levi’s. I wish the sleeves were longer too. They are probably just right for an average height or shorter person. The armholes could be smaller.
The medium wash is a nice medium blue, fairly even in tone. It doesn’t have a lot of stretch but it’s comfortable. The denim is substantial but not too stiff.
Overall, it’s a standard good quality denim jacket without any peculiar style elements or weird cut. It’s good!
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Reviewed in the United States on April 3, 2026
★★★★★ 3
Fabric way to heavy.
Fit Type: Regular, Size: Medium, Color: White
Cute, but material is WAY to heavy, like the heaviest duty denim I've ever seen. Wanted this to be a cute coverup. If you're needing something while breaking broncos or riding your motorcycle would probably be great. I kept it for a while because it was good quality and well made, but it ended up in the donation pile as I'd never wear this.
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Reviewed in the United States on June 10, 2026
★★★★★ 5
Awesome jacket
Fit Type: Regular, Size: Medium, Color: Stone Dark Wash
Love it so not too long or too short but just right and the color is out of sight and fits awesome
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Reviewed in the United States on June 12, 2026
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