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Description
CRX Recombinant Rabbit mAb (SDT-2194-105)Product Specification Host Rabbit Antigen CRX Synonyms Cone rod homeobox protein; CORD2 Immunogen Synthetic Peptide Location Nucleus Accession O43186 Clone Number SDT 2194 105 Antibody Type Recombinant mAb Isotype IgG Application IHC P Reactivity Hu, Ms, Rt Predicted Reactivity Bv, Dg, Gor, Cz, GP Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03%
Product Specification
| Host | Rabbit |
| Antigen | CRX |
| Synonyms | Cone-rod homeobox protein; CORD2 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | O43186 |
| Clone Number | SDT-2194-105 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Bv, Dg, Gor, Cz, GP |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
| IHC-P | 1:1000 | Hu, Ms, Rt |
Background
CRX (Cone-Rod Homeobox) is a 299-amino-acid photoreceptor-specific transcription factor of the OTX-like homeodomain family, encoded by the CRX gene on 19q13.32, that binds to and trans-activates promoters and enhancers of rod and cone photoreceptor genes—including rhodopsin, OPN1SW, OPN1MW, PDE6 subunits and arrestin—via the PCE (photoreceptor conserved element) motif, thereby orchestrating the development, differentiation and daily maintenance of outer-segment structure and phototransduction; autosomal-dominant mutations—missense, truncating, or C-terminal frameshift—cause a spectrum of retinal dystrophies such as cone-rod dystrophy-2, Leber congenital amaurosis-7 and retinitis pigmentosa, while CRX haploinsufficiency or dominant-negative interference disrupts transcriptional networks synergistic with OTX2 and NRL, leading to progressive photoreceptor degeneration and visual impairment.
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