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Description
Human ATRX , His tagProduct Specification Species Human Synonyms Transcriptional regulator ATRX, ATP dependent helicase ATRX, X linked helicase II, X linked nuclear protein (XNP), Znf HX, RAD54L, XH2 Accession P46100 Amino Acid Sequence Protein sequence(P46100, Gly2250 Asn2450, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | Transcriptional regulator ATRX, ATP-dependent helicase ATRX, X-linked helicase II, X-linked nuclear protein (XNP), Znf-HX, RAD54L, XH2 |
| Accession | P46100 |
| Amino Acid Sequence | Protein sequence(P46100, Gly2250-Asn2450, with C-10*His) MGYHEHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNIPTGTNLPPVSFNSQTPYIPFNLGALSAMSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWKENMNLSEAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLISCVQRILMNRRLQQQYNQQQQQQMTYQQATLGHLMMPKPPNLIMNPSNGGGGSHHHHHHHHHH |
| Expression System | E.coli |
| Molecular Weight | Theoretical:24.9kDa Actual:27kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
Transcriptional regulator ATRX also known as ATP-dependent helicase ATRX, X-linked helicase II, or X-linked nuclear protein (XNP) is a protein that in humans is encoded by the ATRX gene. It contains an ATPase / helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. ATRX is required for deposition of the histone variant H3.3 at telomeres and other genomic repeats. These interactions are important for maintaining silencing at these sites. Acquired mutations in ATRX have been reported in a number of human cancers including pancreatic neuroendocrine tumours, gliomas, astrocytomas, osteosarcomas, and malignant pheochromocytomas. There is a strong correlation between ATRX mutations and an Alternative Lengthening of Telomeres (ALT) phenotype in cancers.
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4.5 ★★★★★
Based on 469 reviews
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Product Reviews
★★★★★ 5
XL was way too big for me
Size: X-Large, Color: Black
Jacket is flashy and made better than I expected. I'm 6ft 1in, 215lbs with a 45" chest and I was swimming in the XL. Sleeves were too long for me and I have long arms. I've ordered the next size down and hope they give a refund on this size for me.
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Reviewed in the United States on December 24, 2024
★★★★★ 3
Insanely small
Size: 3X-Large, Color: Golden
The jacket is well made and seems to hold the sequins well. However it runs very, very small. I am 6’1” 280lbs, I wear a 2XL shirt comfortably and the 3XL shirt I have I’m swimming in. I bought a 3XL because I read it ran small. However I can barely get this on. I’d say this 3XL jacket is probably a regular Large, MAYBE an XL.
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Reviewed in the United States on April 29, 2026
★★★★★ 5
Perfect for the occasion
Size: Small, Color: Purple
Fit was great and true to size. I am 5'6" 140 lbs. and wear 38S jacket. Ordered a small.
Bought this for a "Prom" theme party. Everyone commented on it. It's not a high quality garment. But for something like new years eve party or a night out in Vegas it's perfect.
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Reviewed in the United States on December 15, 2024
★★★★★ 5
Perfect
Size: Large, Color: Black
We got this for my son for prom last year and it's a beautiful jacket! No complaints.
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Reviewed in the United States on March 5, 2026
★★★★★ 5
Excellent!!!
Love it, have another color form this company
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Reviewed in the United States on August 5, 2025